Extended Water Fasts and age

This is the reply from the Gemini AI engine when I asked if extended Water Fasts kill senescent old age cells.

But before the AI answer, I'll write a few paragraphs to explain senescence, that is,  old age. It starts when you're born. Senescent cells accumulate and toxify your system early on. That's the nature of life living in an environment like earth.

Bear in mind that my 40 Fasts reduced my biologic age 5 1/2 years according to the last DNA methylation test I had run 3 months ago. 

Also bear in mind that at age 60, 15% of your body is senescent cells. If you look close at a 25 year old, you can see a bunch of tiny senescent cell bumps that already form. Also if you're older than that, you can feel the unevenness below your skin.

Can you reduce your biologic age with extended Water fasting? Yes I believe so. That what it did to me.

This is link to the studies scientists did on the therapeutic zones of autophagy in studying brain cancer. You'll see when the therapeutic zone is crossed, using the glucose/ketone levels in the blood stream. Scroll down to the graph. The GKI index as they call it. I cross that barrier after my 3rd day of fasting. That's why I  do a 4 day water fast. 

https://pmc.ncbi.nlm.nih.gov/articles/PMC4367849/



Here is the AI answer when I asked this question:

Does prolonged water fasting kill senescent cells?

 Yes, there is evidence suggesting that prolonged water fasting can contribute to the killing or reduction of senescent cells through several mechanisms, primarily via the induction of autophagy.

Here's a breakdown of how prolonged water fasting is thought to affect senescent cells:

 * Induction of Autophagy: Prolonged fasting is a known trigger for autophagy, a cellular "self-cleaning" process where damaged components, including potentially senescent cells or their components, are broken down and recycled. Several studies indicate that fasting and calorie restriction promote autophagy, which can help clear out damaged cells, including senescent ones.

 * Reduction of Pro-growth Signaling: Prolonged fasting can reduce levels of insulin-like growth factor 1 (IGF-1) and the activity of protein kinase A (PKA). These pathways are associated with cell growth and aging. By reducing their activity, fasting may shift the cellular state towards maintenance and repair, potentially impacting senescent cells.

 * Senolysis: While "senolysis" specifically refers to the selective destruction of senescent cells, some research suggests that the cellular stress induced by prolonged fasting, coupled with the activation of autophagy, could contribute to the death of these damaged cells.

 * Impact on Senescence-Associated Secretory Phenotype (SASP): Some studies have explored the impact of prolonged fasting on the SASP, the cocktail of inflammatory molecules secreted by senescent cells. While some initial findings might show an increase in certain SASP markers during fasting, the overall long-term effect, particularly in the re-feeding phase, is thought to potentially lead to a reduction in the burden of senescent cells and their associated inflammation.

Important Considerations:

 * Duration and Repetition: The duration of the water fast needed to significantly impact senescent cells is not definitively established in human studies. Research often involves periods of 48 hours or more. Furthermore, cycles of fasting may be more effective than single prolonged fasts.

 * More Research Needed: While preclinical studies (in animals and cell cultures) show promising results, more robust human research is necessary to fully understand the effects of prolonged water fasting on senescent cells and their clinical significance.

 * Individual Variability: The response to prolonged fasting can vary significantly between individuals due to genetic factors, health status, and other lifestyle factors.

 * Not a Sole Solution: Prolonged fasting should not be considered the only or necessarily the primary strategy for addressing senescent cells. Other lifestyle interventions like exercise, a healthy diet rich in senolytic compounds, and stress management also play a role.

In conclusion, the current evidence suggests that prolonged water fasting can likely contribute to the reduction of senescent cells through mechanisms like autophagy. However, more research is needed to fully elucidate the optimal protocols and long-term effects in humans.

----------‐-‐-----

So you see, even the AI engine knows how to reduce your age and live an extended healthier life.

Pierre

Comments

Post a Comment

Popular posts from this blog

Saving images locally

 Done, done, done. Here's the way it works  Let's say you want to look at a sagging arm's skin.  So when you save them under the sagging skin condition, the pictures you upload will actually be saved in the machine you're using.Then, if you switch to a different machine, you save/export to a file. This file can be then be used to add the pictures to any other machine.  That way you can compare pictures on any other machine, you just import them in.  The drawback is this: when you import you'll need to make sure you've exported your latest pictures because the import replaces everything. Anyway, it works. A bit cumbersome, but it does allow multiple machines and I won't run out of room on my server. As a side note, Claude 3.5 Sonnet wrote the software. I had no idea how to manipulate an indexedDB database in a browser's local storage. And to top it off, importing and exporting from that local store. Yet, if you don't understand how to finesse an AI, i...
Read more

My fast

 So today I'm ending a 3 1/2 day water fast. I usually do 4 days but i can end this early. The whole idea, for me is to fix various conditions my body accumulated over 73 years of life. For me, mainly my eye problems and also arthritis and many others. To fix these, I have to stay below 1.5 on the GKI index for 24 hours. That's my goal on every fast , so on my third day, at 10 am, I dropped below 1.5. So today at 10, I can eat again. My website explains GKI. Mywaterfasts.com.  The idea on a fast is to starve the cells enough to wake up the lysosomes in my cells. They're little stomachs that magically appear to remove old broken cells and organelles inside cells. They're the ones that kill virus and bacteria when you're sick. So I cut 1/2 day off my fast by rapidly using up my stored glucose. I did that by taking the 10 1/2 mile bicycle ride on the Back Bay Loop in Newport Beach, on my first day of fasting.  The next day, I did another 5 miles on the Fullerton loop. ...
Read more

Saving condition images

 Dealing with images is a complicated set of circumstances. First, if I'm going to keep track of all my different condition pictures, it can overwhelm my web hosting server pretty quickly. Just me, no problem, but, add a few people to the mix and it starts taking significant amounts of room. To deal with all those images, i needed to pull out my deep thinking cap. So here is the way I'll do it.  There is a way for me to store information on a user's machine. It's called indexedDB. The problem is this, it has to be extremely secure, so the way an internet browser deals with it, is that it saves information locally but is only accessible from that browser and that website. Different browser, different data repository. So... how to deal with such diversity, especially considering that the user has multiple machines. The only way I can see them being able to access thir images is to use deep Synchronization techniques. So, first, if they are on their smartphones, then let t...
Read more